Clarithromycin Impurity 15(Clarithromycin EP Impurity O) - Names and Identifiers
Name | Clarithromycin (9Z)-O-Methyloxime
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Synonyms | ClarithroMycin Identity Clarithromycin (9Z)-O-Methyloxime (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R,Z) Erythromycin, 6-O-methyl-, 9-O-methyloxime, (9Z)- Clarithromycin Impurity 15(Clarithromycin EP Impurity O) (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R,Z)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-12,13-dihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-10-(methoxyimino)-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one
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CAS | 127252-80-6
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Clarithromycin Impurity 15(Clarithromycin EP Impurity O) - Physico-chemical Properties
Molecular Formula | C39H72N2O13
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Molar Mass | 776.99 |
Density | 1.23±0.1 g/cm3(Predicted) |
Melting Point | >116oC (dec.) |
Boling Point | 812.6±75.0 °C(Predicted) |
Solubility | Chloroform (Slightly), Methanol (Very Slightly) |
Appearance | Solid |
Color | Off-White to Pale Beige |
pKa | 13.02±0.70(Predicted) |
Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
Stability | Hygroscopic |
Clarithromycin Impurity 15(Clarithromycin EP Impurity O) - Introduction
Clarithromycin (9Z)-O-Methyloxime, chemical name (Clarithromycin (9Z)-O-methoxamine) is a drug impurity. The following is some information on the nature, use, formulation and safety of Clarithromycin (9Z)-O-Methyloxime:
Nature:
Clarithromycin (9Z)-O-Methyloxime is an organic compound with a chemical formula of C37H64N2O16 and a relative molecular mass of 788.9g/mol. It belongs to a possible metabolite of the macrolide antibiotic clarithromycin. It is a white crystalline solid, stable at room temperature.
Use:
Clarithromycin (9Z)-O-Methyloxime has not been extensively studied or used clinically. In the research field, it may be used as an analytical standard for clarithromycin and its metabolites for pharmacokinetic studies or pharmacokinetic evaluation.
Preparation Method:
The preparation method of Clarithromycin (9Z)-O-Methyloxime is usually synthesized by chemical reaction. The specific preparation method may vary depending on the experimental conditions and research purposes.
Safety Information:
Since Clarithromycin (9Z)-O-Methyloxime has not been widely used or studied, detailed information about its safety and toxicity is unclear. When handling Clarithromycin (9Z)-O-Methyloxime, it is necessary to follow the principles of good laboratory practice and take appropriate protective measures, such as wearing laboratory gloves and protective glasses.
Last Update:2024-04-09 21:04:16